Targaba tablets are prescribed for the treatment of various types of neuropathic pain, including:
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Mirogabalin is a derivative of gamma-aminobutyric acid (GABA) that targets the α2δ subunits of voltage-gated calcium channels (VGCCs). By inhibiting calcium ion influx and neurotransmitter release at presynaptic neurons, it helps reduce the hyperexcitability of neurons in the central nervous system (CNS), thereby relieving neuropathic pain.
After oral administration, Mirogabalin is quickly absorbed, with peak plasma concentrations occurring within 0.5 to 1.5 hours. It has low protein binding (about 25%) and a volume of distribution ranging from 64 to 88 liters. The drug is primarily excreted unchanged by the kidneys (61–72%), with minor hepatic metabolism mediated by UGT enzymes. Its elimination half-life ranges from 2 to 4.9 hours. Nearly all the drug is expelled through urine, with only 1% excreted in feces.
Severe fatigue, loss of appetite, nausea, vomiting, or jaundice (signs of liver dysfunction)
Adults:
Start with 5 mg twice daily. Depending on age and response, the dose can be increased by 5 mg increments weekly, up to 15 mg twice daily.
Children and Adolescents:
Safety and efficacy in this group have not been established.
Hepatic Impairment:
A single 15 mg dose has shown no serious adverse effects in mild to moderate liver dysfunction. No data available for severe hepatic impairment.
Renal Impairment:
Take only under medical supervision.
With other medicines: Coadministration with Cimetidine or Probenecid may raise Mirogabalin levels. Combining with Lorazepam may enhance sedative effects.
Mirogabalin is a substrate for transporters like OAT1, OAT3, OCT2, MATE1, MATE2-K, and UGT. It neither inhibits nor induces CYP enzymes or major transporters, but combining with inhibitors of these transporters may increase drug exposure.
With food and alcohol, Food has no significant impact on absorption. Avoid alcohol as it can intensify dizziness and sedation caused by Targaba.
Use during pregnancy only when the benefits clearly outweigh potential risks.
Animal studies show passage through the placenta and secretion into breast milk. Consult your doctor to evaluate whether breastfeeding should continue during treatment.
Store below 30°C in a dry place, protected from light and moisture.
Keep out of reach of children.
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