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Targaba 10 Tablet 1 Strip
Targaba tablets are prescribed for the treatment of various types of neuropathic pain, including:
- Diabetic Peripheral Neuropathic Pain (DPNP)
- Postherpetic Neuralgia (PHN)
- Peripheral Neuropathic Pain (PNP)
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✅ Description:
Mirogabalin is a derivative of gamma-aminobutyric acid (GABA) that targets the α2δ subunits of voltage-gated calcium channels (VGCCs). By inhibiting calcium ion influx and neurotransmitter release at presynaptic neurons, it helps reduce the hyperexcitability of neurons in the central nervous system (CNS), thereby relieving neuropathic pain.
After oral administration, Mirogabalin is quickly absorbed, with peak plasma concentrations occurring within 0.5 to 1.5 hours. It has low protein binding (about 25%) and a volume of distribution ranging from 64 to 88 liters. The drug is primarily excreted unchanged by the kidneys (61–72%), with minor hepatic metabolism mediated by UGT enzymes. Its elimination half-life ranges from 2 to 4.9 hours. Nearly all the drug is expelled through urine, with only 1% excreted in feces.
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✔️ Side Effects
- Drowsiness
- Dizziness
- Edema
- Weight gain
- Seek immediate medical attention if any of the following occur:
- Lightheadedness or impaired consciousness
Severe fatigue, loss of appetite, nausea, vomiting, or jaundice (signs of liver dysfunction)
✔️ Dosage & Administration
Adults:
Start with 5 mg twice daily. Depending on age and response, the dose can be increased by 5 mg increments weekly, up to 15 mg twice daily.
Children and Adolescents:
Safety and efficacy in this group have not been established.
Hepatic Impairment:
A single 15 mg dose has shown no serious adverse effects in mild to moderate liver dysfunction. No data available for severe hepatic impairment.
Renal Impairment:
- Mild: Start with 5 mg twice daily, titrate up to 10 mg twice daily.
- Moderate: Start with 2.5 mg twice daily, titrate up to 7.5 mg twice daily.
- Severe: Start with 2.5 mg once daily, increase weekly by 2.5 mg to a maximum of 7.5 mg once daily.
Take only under medical supervision.
✔️ Drug Interactions
With other medicines: Coadministration with Cimetidine or Probenecid may raise Mirogabalin levels. Combining with Lorazepam may enhance sedative effects.
Mirogabalin is a substrate for transporters like OAT1, OAT3, OCT2, MATE1, MATE2-K, and UGT. It neither inhibits nor induces CYP enzymes or major transporters, but combining with inhibitors of these transporters may increase drug exposure.
With food and alcohol, Food has no significant impact on absorption. Avoid alcohol as it can intensify dizziness and sedation caused by Targaba.
✔️ Mirogabalin is contraindicated in:
- Individuals with known hypersensitivity to the drug
- Patients with mild to moderate hepatic or renal impairment
✔️ Use During Pregnancy and Lactation
Use during pregnancy only when the benefits clearly outweigh potential risks.
Animal studies show passage through the placenta and secretion into breast milk. Consult your doctor to evaluate whether breastfeeding should continue during treatment.
✔️ Precautions
- Targaba may cause dizziness, drowsiness, or visual disturbances—patients should avoid driving or operating heavy machinery.
- Elderly patients should use with caution due to the risk of falls and fractures.
- Weight gain, blurred or double vision may occur; report these symptoms to your doctor.
- Dose adjustments are essential in renal impairment. Always inform your doctor about other medications before starting Targaba.
- Discontinue the drug and seek medical advice if allergic reactions develop.
✔️ Storage Conditions
Store below 30°C in a dry place, protected from light and moisture.
Keep out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
